THE SERUM CONCENTRATION OF ACTIVE TRANSFORMING GROWTH-FACTOR-BETA IS SEVERELY DEPRESSED IN ADVANCED ATHEROSCLEROSIS

被引：362

作者：

GRAINGER, DJ

KEMP, BR

METCALFE, JC

LIU, AC

LAWN, RM

WILLIAMS, NR

GRACE, AA

SCHOFIELD, PM

CHAUHAN, A

机构：

[1] STANFORD UNIV, SCH MED, FALK CARDIOVASC RES CTR, STANFORD, CA 94305 USA

[2] PAPWORTH HOSP NHS TRUST, DEPT CARDIOL, CAMBRIDGE CB3 8RE, ENGLAND

来源：

NATURE MEDICINE | 1995年 / 1卷 / 01期

关键词：

D O I：

10.1038/nm0195-74

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent evidence has led us to propose that transforming growth factor-beta (TGF-beta) is a key inhibitor of atherosclerosis. We show here that a population of patients with advanced atherosclerosis all have less active TGF-beta in their sera than patients with normal coronary arteries, with a fivefold difference in average concentration between the two groups. This correlation with atherosclerosis is much stronger than for other known major risk factors and it may therefore have important diagnostic and prognostic significance. Aspirin medication correlates with an increase in active TGF-beta concentration, indicating that therapeutic interventions for TGF-beta are possible.

引用

页码：74 / 79

页数：6

共 26 条

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