GASTRIC-EMPTYING OF SOLIDS BUT NOT LIQUIDS IS DECREASED IN RATS WITH CHRONIC-RENAL-FAILURE

被引：15

作者：

RAYBOULD, HE ^{[1
]}

PLOURDE, V ^{[1
]}

ZITTEL, T ^{[1
]}

BOVER, J ^{[1
]}

QUINTERO, E ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,BRAIN RES INST,LOS ANGELES,CA 90024

来源：

DIGESTIVE DISEASES AND SCIENCES | 1994年 / 39卷 / 11期

关键词：

RENAL FAILURE; NITRIC OXIDE; GASTRIC MOTILITY; L-NAME; UREMIA;

D O I：

10.1007/BF02087642

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Severe gastric complications occur in uremic patients, yet few studies have addressed the effect of chronic renal failure (RF) on gastric physiology. In the present study, we investigated: (1) the effect of RF on gastric emptying of liquids and solids in awake rats, (2) the motor function in the gastric corpus, and (3) the role of nitric oxide in any alterations in gastric motor function in uremic rats. RF was induced by partial kidney infarction. RF had no effect on gastric emptying of liquids but significantly inhibited gastric emptying of solids by 68%. N-Nitro-L-arginine, an inhibitor of nitric oxide (NO) synthesis, had no effect on the reduced gastric emptying of solids in RF rats. RF rats showed an altered pattern of gastric motility compared to sham-operated rats. These data suggest that RF induced an inhibition of gastric emptying of solids, but not liquids. However, NO does not seem to play a role in this inhibition.

引用

页码：2301 / 2305

页数：5

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