CHANGES IN THE CAPILLARITY OF SKELETAL-MUSCLE IN THE GROWING-RAT

被引:93
作者
RIPOLL, E [1 ]
SILLAU, AH [1 ]
BANCHERO, N [1 ]
机构
[1] UNIV COLORADO, MED CTR, SCH MED, DEPT PHYSIOL, DENVER, CO 80262 USA
来源
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 1979年 / 380卷 / 02期
关键词
Capillary density; Capillary to fiber ratio; Fiber composition; Fiber cross sectional area; Skeletal muscle;
D O I
10.1007/BF00582151
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Capillary density (CD), capillary to fiber ratio (C/F), fiber cross sectional area (FCSA) and fiber composition were measured in the soleus and the gastrocnemius (medial head) muscles of rats weighing between 99 and 666 g. Muscle samples obtained from the anesthetized animal were rapidly frozen (-130°C) sliced transversely at 16-18 μm, and treated histochemically by the ATPase method after preincubation at pH's of 4.0 and 4.4 to visualize capillaries and typify fibers. In both muscles the FCSA was positively related to body weight (BW) and muscle weight. At a given BW, the FCSA of the soleus was greater than that of the gastrocnemius. In both muscles CD decreased hyperbolically with FCSA (soleus: CD=1.0613 ×106/FCSA+298.71; gastrocnemius: CD=1.0349 ×106/FCSA+240.74). At the same time a positive linear correlation between C/F and FCSA was found (soleus: C/F=3.92×10-4 FCSA+0.82; gastrocnemius: C/F=2.90×10-4 FCSA+0.93). At a given FCSA, CD and C/F were greater in the soleus than in the gastrocnemius because of differences in fiber composition between the two muscles. The soleus had only oxidative fibers (STO and FTOG) whereas the gastrocnemius had 54% glycolytic fibers (FTG). The very large variability in CD and C/F values reported in the literature could, in part, be due to the differences in capillarity observed with maturation. A change in fiber composition with BW was observed in the soleus, but no systematic change occurred in the gastrocnemius. © 1979 Springer-Verlag.
引用
收藏
页码:153 / 158
页数:6
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