CUMULATIVE EFFECT OF SURFACTANTS ON CUTANEOUS HORNY LAYERS - LYSOSOME LABILIZING ACTION

被引：17

作者：

IMOKAWA, G

MISHIMA, Y

机构：

[1] Department of Dermatology, Kobe University School of Medicine, Kobe

来源：

CONTACT DERMATITIS | 1979年 / 5卷 / 03期

关键词：

Lysosome labilization; skin roughness; surfactant;

D O I：

10.1111/j.1600-0536.1979.tb04828.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

In order to analyze the role of various surfactants in the abnormal desquamation process of the epidermis in keratodermia type hand dermatitis, the lysosome labilizing effect of surfactants has been investigated by measuring the release of enzymes from lysosomes in vitro using spectrophotometric and gel chromatographic techniques. It has been found that the labilizing effect of surfactants decreases in the order of cationic, anionic, and nonionic surfactants and varies with its alkyl chain length. The relationship of the labilization and skin roughness inducing effect is also discussed. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：151 / 162

页数：12

共 27 条

[1]

APPLEMANS F, 1955, BIOCHEM J, V59, P438

[2]

BERRS RF, 1952, J BIOL CHEM, V195, P133

[3] PENETRATION OF ANIONIC SURFACTANTS (SURFACE ACTIVE AGENTS) INTO SKIN .1. PENETRATION OF SODIUM LAURATE AND SODIUM DODECYL SULFATE INTO EXCISED HUMAN SKIN [J].