Stem cell transplantation and functional recovery after spinal cord injury: a systematic review and meta-analysis

被引：34

作者：

Abbaszadeh, Hojjat-Allah ^{[1
,2
]}

Niknazar, Somayeh ^{[1
]}

Darabi, Shahram ^{[3
]}

Roozbahany, Navid Ahmady ^{[1
,7
]}

Noori-Zadeh, Ali ^{[4
]}

Ghoreishi, Seyed Kamran ^{[5
]}

Khoramgah, Maryam Sadat ^{[6
]}

Sadeghi, Yousef ^{[1
,2
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Loghman Hakim Med Ctr, Hearing Disorders Res Ctr, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Sch Med, Dept Biol & Anat Sci, POB 19395-4719, Tehran, Iran

[3] Qazvin Univ Med Sci, Cellular & Mol Res Ctr, Qazvin, Iran

[4] Ilam Univ Med Sci, Fac Paramed, Dept Clin Biochem, Ilam, Iran

[5] Univ Qom, Dept Stat, Qom, Iran

[6] Shahid Beheshti Univ Med Sci, Sch Med, Dept Biotechnol, Tehran, Iran

[7] Ryerson Univ, G Raymond Chang Sch, Toronto, ON, Canada

来源：

ANATOMY & CELL BIOLOGY | 2018年 / 51卷 / 03期

关键词：

Stem cell therapy; Spinal cord injuries; Meta-analysis; Contusions;

D O I：

10.5115/acb.2018.51.3.180

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 [人体解剖与组织胚胎学];

摘要：

Spinal cord injury is a significant cause of motor dysfunctions. There is no definite cure for it, and most of the therapeutic modalities are only symptomatic treatment. In this systematic review and meta-analysis, the effectiveness of stem cell therapy in the treatment of the spinal cord injuries in animal models was studied and evaluated. A systematic search through medical databases by using appropriate keywords was conducted. The relevant reports were reviewed in order to find out cases in which inclusion and exclusion criteria had been fulfilled. Finally, 89 articles have been considered, from which 28 had sufficient data for performing statistical analyses. The findings showed a significant improvement in motor functions after cell therapy. The outcome was strongly related to the number of transplanted cells, site of injury, chronicity of the injury, type of the damage, and the induction of immune-suppression. According to our data, improvements in functional recovery after stem cell therapy in the treatment of spinal cord injury in animal models was noticeable, but its outcome is strongly related to the site of injury, number of transplanted cells, and type of transplanted cells.

引用

页码：180 / 188

页数：9

共 41 条

[1]

Abbaszadeh Hojjat Allah, 2018, Iranian Biomedical Journal, V22, P246, DOI 10.22034/ibj.22.4.246

[2]

Human ciliary neurotrophic factor-overexpressing stable bone marrow stromal cells in the treatment of a rat model of traumatic spinal cord injury [J].