ULTRASTRUCTURAL ALTERATIONS IN PLASMA-MEMBRANES FROM DRUG-RESISTANT P388 MURINE LEUKEMIA-CELLS

被引：20

作者：

GARCIASEGURA, LM

FERRAGUT, JA

FERRERMONTIEL, AV

ESCRIBA, PV

GONZALEZROS, JM

机构：

[1] UNIV ALICANTE,SCH MED,DEPT NEUROCHEM,E-03080 ALICANTE,SPAIN

[2] CSIC,CAJAL INST,MADRID 6,SPAIN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1029卷 / 01期

关键词：

Anthracycline; Cellular multidrug resistance; Chemotherapy drug; Daunomycin; Freeze-fracture; Intramembrane particle; Membrane protein;

D O I：

10.1016/0005-2736(90)90454-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Freeze-fracture studies of daunomycin-sensitive and daunomycin-resistant P388 cell lines, reveal a significant increase in the numerical density of intramembrane particles at both, the protoplasmic and the exoplasmic leaflets of the plasma membrane from the drug-resistant cells. Such change in plasma membrane architecture is not accompanied by overexpression of P-glycoproteins. Furthermore, drug-sensitive cells exhibited an increased number of exo-endocytotic images when compared to drug-resistant cells. Our observations suggest that there are global changes in the structural organization of the plasma membrane, which are related to the acquisition of the cellular drug-resistant phenotype. © 1990.

引用

页码：191 / 195

页数：5

共 19 条

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