TOPICAL TREATMENT WITH 5-AMINOSALICYLIC IN DISTAL ULCERATIVE-COLITIS BY USING A NEW SUPPOSITORY PREPARATION - A DOUBLE-BLIND PLACEBO CONTROLLED TRIAL

被引：44

作者：

CAMPIERI, M

GIONCHETTI, P

BELLUZZI, A

BRIGNOLA, C

TAMPIERI, M

IANNONE, P

BRUNETTI, G

MIGLIOLI, M

BARBARA, L

机构：

[1] Institute of Clinical Medicine and Gastroenterology, University of Bologna

[2] Giuliani Medical Department, Milano

来源：

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE | 1990年 / 5卷 / 02期

关键词：

D O I：

10.1007/BF00298473

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Sixty-two patients with ulcerative colitis localised to the distal sigmoid colon and rectum (<20 cm) entered the trial. Thirty-two were treated with 5-ASA 500 mg suppositories (Asacol) 3 times a day for 1 month while 30 received a placebo given in the same regime. Clinical, sigmoidoscopic and histological assessment was carried out before, after 15 days and after 1 month of treatment. At the end of the study 5-ASA suppositories showed significantly better results in all the parameters recorded than placebo (p<0.01). There were no unwanted effects related to the use of suppositories. This treatment should therefore be offered as a first choice for patients with distal rectosigmoiditis. © 1990 Springer-Verlag.

引用

页码：79 / 81

页数：3

共 9 条

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