ON THE SPONTANEOUS ADHERENCE OF MYELIN BASIC-PROTEIN TO LYMPHOCYTES-T

被引：4

作者：

BOBBA, A

MUNNO, I

GRECO, B

PELLEGRINO, NM

RICCIO, P

JIRILLO, E

QUAGLIARIELLO, E

机构：

[1] UNIV BARI,DIPARTIMENTO BIOCHIM & BIOL MOLEC,I-70124 BARI,ITALY

[2] CNR,CTR STUDIO MITOCONDRI & METAB ENERGET,I-70126 BARI,ITALY

[3] UNIV BARI,CATTEDRA IMMUNOL,I-70124 BARI,ITALY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 180卷 / 02期

关键词：

D O I：

10.1016/S0006-291X(05)81183-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have applied a double tagging system in order to study whether purified myelin basic protein is able to adhere to normal human peripheral T lymphocytes without the need to purify cells. Evaluation of myelin basic protein adherence to peripheral blood mononuclear cells was determined with biotinylated myelin basic protein and fluoresceinated avidin, and lymphocyte population was identified by the corresponding phycoerythrinated monoclonal antibody. The observed adherence of myelin basic protein to T lymphocytes was found to depend on protein conformation. © 1991 Academic Press, Inc.

引用

页码：1125 / 1129

页数：5

共 14 条

[1]

Bobba A, 1991, Acta Neurol (Napoli), V13, P133

[2]

BOYUM A, 1968, SCAND J CLIN LAB INV, VS 21, P77

[3] VESICULAR DISRUPTION OF MYELIN IN AUTOIMMUNE DEMYELINATION [J].