AN INVESTIGATION INTO THE ROLE OF INFLAMMATORY CELLS IN DUPUYTRENS DISEASE

被引：31

作者：

ANDREW, JG ^{[1
]}

ANDREW, SM ^{[1
]}

ASH, A ^{[1
]}

TURNER, B ^{[1
]}

机构：

[1] CHESTERFIELD & N DERBYSHIRE ROYAL HOSP,SHEFFIELD,ENGLAND

来源：

JOURNAL OF HAND SURGERY-BRITISH AND EUROPEAN VOLUME | 1991年 / 16B卷 / 03期

关键词：

D O I：

10.1016/0266-7681(91)90051-O

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

An immunohistochemical study was performed on nodules excised from the palmar fascia of patients with Dupuytren's contracture. In cellular nodules, antibodies to actin (used as a marker for myofibroblasts), desmin, vimentin, Mac 387 (a macrophage marker) and leucocyte common antigen were used. A correlation was demonstrated between the numbers of macrophages and the presence of myofibroblasts. The presence of myofibroblasts is generally considered to indicate the active stage of the disease. Inflammatory cells other than macrophages were largely absent from the nodules, although lymphocytes were frequent in the tissue around the nodules. Microvascular changes were prominent in the nodules and pericyte proliferation was observed around occluded capillaries. Release of growth factors from macrophages may be important in Dupuytren's contracture, as is the case in other fibrotic diseases. The possible role of macrophages in the aetiology of Dupuytren's disease is discussed.

引用

页码：267 / 271

页数：5

共 28 条

[1]

AZZARONE B., FAILLY-CREPIN C., DAYA-GROSJEAN L., CHAPONNIER C., GABBIANI C., Abnormal Behaviour of Cultured Fibroblasts from Nodule and Nonaffected Aponeurosis of Dupuytren’s Disease, Journal of Cellular Physiology, 117, pp. 353-361, (1983)

[2]

BARSKY S., GOPALAKRISHNA R., Isolation of a myofibroblast growth factor from human breast carcinoma cell lines, Biochemical and Biophysical Research Communications, 149, 3, pp. 1125-1131, (1987)

[3]

BUNNING R., CRAWFORD A., RICHARDSON H., OPDENAKKER G., VAN DAMME J., RUSSELL R., Interleukin 1 preferentially stimulates the production of tissue-type plasminogen activator by human articular chondrocytes, Biochemica et Biophysics Acta, 924, pp. 473-482, (1987)

[4]

CLARKSON P., The aetiology of Dupuytren’s disease, Guy’s Hospital Reports, 110, pp. 52-62, (1961)

[5]

GELBERMAN R., AMIEL D., RUDOLPH R., VANCE R., Dupuytren’s Contracture. An Electron Microscopic, Biochemical and Clinical Correlative Study, Journal of Bone and Joint Surgery, 62A, 3, (1980)

[6]

GOKEL J., HUBNER G., Occurrence of Myofibroblasts in the Different Phases of Morbus Dupuytren (Dupuytren’s Contracture), Beitr. Path, 161, pp. 166-175, (1977)

[7]

HUNT T., BANDA M., SILVER I., Bailey A., Cell interactions in posttraumatic fibrosis, Fibrosis, pp. 127-149, (1985)

[8]

ISELIN M., Hueston J., Tubiana R., Mysterious aspects of Dupuytren’s Disease, Dupuytren’s Disease, pp. 67-70, (1974)

[9]

JOZSA L., SALAMON A., REFFY A., RENNER A., DEMEL S., DONHOFFER A., PINTER T., THORING J., Fine structural alterations of the palmar aponeurosis in Dupuytren’s contracture. A combined scanning and transmission electromicroscopic examination, Zentralblatt fur allgemeine Pathologie und pathologische Anatomie (Jena), 134, pp. 15-25, (1988)

[10]

KISCHER C., SPEER D., Microvascular changes in Dupuytren’s contracture, Journal of Hand Surgery, 9A, 1, pp. 58-62, (1984)

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