THE COMPLETE SEQUENCE OF A PLASMODIUM MALARIAE SSURRNA GENE AND ITS COMPARISON TO OTHER PLASMODIAL SSURRNA GENES

被引：40

作者：

GOMAN, M

MONS, B

SCAIFE, J

机构：

[1] UNIV EDINBURGH,DEPT MOLEC BIOL,KINGS BLDG,MAYFIELD RD,EDINBURGH EH9 3JR,MIDLOTHIAN,SCOTLAND

[2] LEIDEN STATE UNIV,PARASITOL LAB,JOINT PARASITOL GRP,2312 AV LEIDEN,NETHERLANDS

[3] TNO,ITRI,CTR PRIMATE,2280 HV RIJSWIJK,NETHERLANDS

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1991年 / 45卷 / 02期

关键词：

PLASMODIUM-MALARIAE; SSURRNA; 5.8S RNA; DIAGNOSTIC PROBE;

D O I：

10.1016/0166-6851(91)90096-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A gene encoding the small subunit rRNA (SSUrRNA) has been isolated from the human malaria parasite, Plasmodium malariae. The gene has been sequenced. It contains conserved and variable regions which conform to patterns established for other eukaryotic SSUrRNA genes. Comparisons with other SSUrRNA genes from Plasmodium species reveal regions unique to P. malariae which could be used in specific diagnostic probes for this organism, and provide evidence that the gene is of the type expressed during asexual growth. In addition the '5.85' gene has been cloned from P. malariae. The gene has been sequenced. It contains bases universally conserved in '5.85' genes but there is considerable divergence between the P. malariae sequence and that of the P. falciparum gene.

引用

页码：281 / 288

页数：8

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