NO ASSOCIATION WITH HLA-DR, HLA-DQ OR HLA-DP ALLELES IN GUILLAIN-BARRE-SYNDROME

被引：20

作者：

HILLERT, J

OSTERMAN, PO

OLERUP, O

机构：

[1] KAROLINSKA INST,HUDDINGE HOSP,DEPT NEUROL,HUDDINGE,SWEDEN

[2] KAROLINSKA INST,HUDDINGE HOSP,DEPT CLIN IMMUNOL,HUDDINGE,SWEDEN

[3] UNIV UPPSALA,DEPT NEUROL,S-75105 UPPSALA,SWEDEN

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1991年 / 31卷 / 01期

关键词：

GENETIC SUSCEPTIBILITY; GUILLAIN-BARRE SYNDROME; HLA-D; PLASMAPHERESIS TREATMENT; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; ACUTE INFLAMMATORY POLYRADICULONEUROPATHY; FRAGMENT LENGTH POLYMORPHISM; PLASMA-EXCHANGE; BETA-CHAIN; ANTIGENS; ALPHA; SUBREGION; RFLP;

D O I：

10.1016/0165-5728(91)90088-O

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The distribution of HLA class II alleles in Guillain-Barre' syndrome (GBS) has previously been reported only for HLA-DR. We report here the results of genomic typing for HLA-DR, -DQ and -DP allelic variability by restriction fragment length polymorphism analysis in 49 patients with a history of GBS. No association was found to HLA-DR, -DQ or -DP alleles or HLA-DR-DQ haplotypes. Subgrouping of patients according to severity of disease, as measured by disability or muscular weakness, or response to plasmapheresis treatment, also failed to reveal significant associations. These data suggest that HLA class II genes do not confer susceptibility to GBS.

引用

页码：67 / 72

页数：6

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