ANASTOMOTIC LEAKS IN COLORECTAL-CANCER SURGERY - A RISK FACTOR FOR RECURRENCE

被引：95

作者：

AKYOL, AM

MCGREGOR, JR

GALLOWAY, DJ

MURRAY, GD

GEORGE, WD

机构：

[1] University Department of Surgery, Western Infirmary, Glasgow

来源：

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE | 1991年 / 6卷 / 04期

关键词：

D O I：

10.1007/BF00341385

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

This study examines anastomotic leaks as a potential influence on the long term outcome of patients with colorectal cancer. 167 patients were studied who had clinical and radiological assessment of anastomotic integrity in the post-operative period, following potentially curative resections for left-sided colonic or rectal cancer. There was no evidence of a leak in 135 of these patients, while the remaining 32 developed a clinical and/or a radiological leak. At the end of a mean follow-up of 25 months, 15 patients with leaks (46.9%) developed tumour recurrence, compared with 25 of those without any leak (18.5%; p < 0.001). Cancer specific mortality at 24 months was also significantly higher for patients with leaks (36.9% +/- 9.7% versus 12.6% +/- 3.3%; p < 0.001). The influence of anastomotic leaks on the outcome was independent of tumour stage. These results suggest that in patients undergoing surgery for colorectal cancer development of an anastomotic leak is significantly associated with a poorer long-term outcome.

引用

页码：179 / 183

页数：5

共 15 条

[1]

Ravitch M.M., Canalis F., Weinshelbaum A., McCormick J., Studies in intestinal healing: III Observations on everting intestinal anastomoses, Ann Surg, 166, pp. 670-679, (1967)

[2]

Khoury G.A., Waxman B.P., Large Bowel anastomoses. I. The healing process and sutured anastomoses. A review, Br J Surg, 70, pp. 61-63, (1983)

[3]

Schrock T.R., Deveney C.W., Dunphy J.E., Factors contributing to leakage of anastomoses, Ann Surg, 177, pp. 513-518, (1973)

[4]

Irvin T.T., Goligher J.C., Aetiology of disruption of intestinal anastomoses, Br J Surg, 60, pp. 461-464, (1973)

[5]

Suturing or stapling in gastrointestinal surgery: A prospective randomised study, Br J Surg, 78, pp. 337-341, (1991)

[6]

Manual for staging of cancer, pp. 1-24, (1988)

[7]

Kaplan E.L., Meier P., Nonparametric estimation from incomplete observations, Journal of the American Statistical Association, 53, pp. 457-481, (1958)

[8]

Cox D.R., Regression models and life tables, J R State Soc [B], 34, pp. 187-220, (1972)

[9]

Umpleby H.C., Fermor B., Symes M.O., Williaon R.C.N., Viability of exfoliated colorectal carcinoma cells, Br J Surg, 71, pp. 659-663, (1984)

[10]

Fermor B., Umpleby H.C., Lever J.V., Symes M.O., Williaon R.C.N., The proliferative and metastatic potential of exfoliated colorectal carcinoma cells, J Natl Cancer Inst, 74, pp. 1161-1168, (1985)

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