PHOTODYNAMIC THERAPY OF A MOUSE GLIOMA - INTRACRANIAL TUMORS ARE RESISTANT WHILE SUBCUTANEOUS TUMORS ARE SENSITIVE

被引：13

作者：

LINDSAY, EA

BERENBAUM, MC

BONNETT, R

THOMAS, DGT

机构：

[1] UNIV LONDON QUEEN MARY COLL, DEPT CHEM, LONDON E1 4NS, ENGLAND

[2] INST NEUROL, GOUGH COOPER DEPT NEUROL SURG, LONDON WC1N 3BG, ENGLAND

[3] ST MARYS HOSP, SCH MED, DEPT EXPTL PATHOL, LONDON W2 1PG, ENGLAND

来源：

BRITISH JOURNAL OF CANCER | 1991年 / 63卷 / 02期

关键词：

D O I：

10.1038/bjc.1991.57

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Subcutaneous and intracranial VMDk tumours were treated with photodynamic therapy (PDT) using a new sensitiser, m-THPP. Subcutaneous tumours were highly sensitive to PDT but intracranial tumours were much more resistant, requiring a 30-fold increase in sensitiser dose to produce equivalent levels of necrosis. Resistance of intracerebral tumours was not due to failure of the sensitiser to enter tumours. Necrosis of intracranial tumours was increased when mice breathed 100% oxygen during PDT while subcutaneous tumour necrosis was unaffected.

引用

页码：242 / 246

页数：5

共 27 条

[1] MESO-TETRA(HYDROXYPHENYL)PORPHYRINS, A NEW CLASS OF POTENT TUMOR PHOTOSENSITIZERS WITH FAVORABLE SELECTIVITY [J].