ROLE OF CALMODULIN IN ANTI-DIURETIC HORMONE MEDIATED WATER TRANSPORT

被引：16

作者：

BEAUWENS, R ^{[1
]}

RENTMEESTERS, M ^{[1
]}

机构：

[1] CATHOLIC UNIV LOUVAIN, DEPT PHYSIOL, B-1200 BRUSSELS, BELGIUM

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1981年 / 99卷 / 02期

关键词：

D O I：

10.1016/0006-291X(81)91771-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several classes of tricyclic antidepressants [trifluoperazine, pimozide and chlorpromazine] inhibit the action of antidiuretic hormone (ADH) and cAMP on osmotic H2O flow across toad urinary bladder without any effect on Na transport. Calmodulin apparently is involved in the hydroosmotic action of ADH (and of serosal hypertonicity), possibly in inducing exocytosis at the luminal border of vesicles rich in H2O channels.

引用

页码：491 / 495

页数：5

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