FRACTIONATED STEREOTAXIC EXTERNAL-BEAM RADIOTHERAPY IN THE MANAGEMENT OF BRAIN METASTASES

被引：20

作者：

LAING, RW

WARRINGTON, AP

HINES, F

GRAHAM, JD

BRADA, M

机构：

[1] ROYAL MARSDEN HOSP,NEUROONCOL UNIT,DOWNS RD,SUTTON SM2 5PT,SURREY,ENGLAND

[2] ROYAL MARSDEN HOSP,ACAD UNIT RADIOTHERAPY & ONCOL,SUTTON SM2 5PT,SURREY,ENGLAND

[3] BRISTOL ONCOL CTR,BRISTOL BS2 8ED,AVON,ENGLAND

[4] ROYAL MARSDEN HOSP,DEPT PHYS,SUTTON SM2 5PT,SURREY,ENGLAND

[5] ROYAL MARSDEN HOSP,INST CANC RES,SUTTON SM2 5PT,SURREY,ENGLAND

来源：

EUROPEAN JOURNAL OF CANCER | 1993年 / 29A卷 / 10期

关键词：

D O I：

10.1016/0959-8049(93)90007-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

24 patients with 28 brain metastases were treated with fractionated stereotactic radiotherapy (SRT). Doses ranged from 10 Gy in two fractions to 20 Gy in two fractions. 13 patients received SRT boost after whole brain radiotherapy (WBRT), 5 were treated with SRT alone and 6 were treated at the time of recurrence following WBRT. The median progression-free survival at the treated site was 18 months and the median survival was 18 months. All patients were treated without admission to hospital. Toxicity of fractionated SRT was minimal and patients treated without WBRT did not suffer significant alopecia. Fractionated SRT offers a non-toxic non-invasive alternative to excision surgery in patients with solitary brain metastases. The optimum fractionation schedule and the role of whole brain irradiation remain to be determined.

引用

页码：1387 / 1391

页数：5

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