EFFECTS OF CYCLOOXYGENASE INHIBITION UPON GLUTAMATE RELEASE FROM RAT CEREBELLUM

被引：10

作者：

DICKIE, BGM ^{[1
]}

ANNELS, SJ ^{[1
]}

DAVIES, JA ^{[1
]}

机构：

[1] UNIV WALES COLL CARDIFF,COLL MED,DEPT PHARMACOL & THERAPEUT,CARDIFF CF4 4XN,S GLAM,WALES

来源：

NEUROREPORT | 1994年 / 5卷 / 04期

关键词：

GLUTAMATE; CEREBELLUM; FLURBIPROFEN; CYCLOOXYGENASE INHIBITION; ARACHIDONIC ACID;

D O I：

10.1097/00001756-199401120-00005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

ARACHIDONIC acid has been proposed as a diffusible second messenger in the CNS with a pathophysiological role in epilepsy and stroke and a physiological role in longterm potentiation. These actions are possibly due to the ability of arachidonic acid to enhance extraneuronal glutamate concentration. In this present study we have investigated the effect of flurbiprofen, a cyclo-oxygenase inhibitor, on both potassium- and veratridine-stimulated release of glutamate from rat cerebellar slices. Flurbiprofen (100-500 mu M) had no effect on basal release but significantly increased stimulated release. The NMDA receptor antagonist CPP abolished the flurbiprofen-induced potentiation to both modes of stimulation, whilst the metabotropic glutamate receptor antagonist, L-AP3, blocked potassium-stimulated enhancement but had a variable effect on veratridine-stimulated release.

引用

页码：393 / 396

页数：4

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