A LAMELLAR LIQUID-CRYSTAL WITH FOSINOPRIL SODIUM

被引：5

作者：

FRIBERG, SE

MOADDEL, T

MORRIS, KR

ABRAMOWITZ, R

AMSBERRY, KL

机构：

[1] CLARKSON UNIV,DEPT CHEM,POTSDAM,NY 13699

[2] BRISTOL MYERS SQUIBB CO,NEW BRUNSWICK,NJ 08903

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1994年 / 83卷 / 05期

关键词：

D O I：

10.1002/jps.2600830517

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The location and conformation of fosinopril sodium (FS) in a lamellar liquid crystal of water, sodium dodecyl sulfate, and decanol was studied by low-angle X-ray diffraction. The result showed the FS molecule to be located within the amphiphilic part of the liquid crystalline structure with the polar parts anchored at the water/polar part interface. An area per molecule in the range of 95-100 Angstrom(2) showed not only the polar groups but also the benzene ring to be located at this interface.

引用

页码：677 / 679

页数：3

共 28 条

[1]

[Anonymous], ADV LIQUID CRYSTALS

[2]

AUVARY X, 1989, J PHYS CHEM-US, V93, P7458

[3] X-RAY-DIFFRACTION STUDY OF MESOPHASES OF CETYLTRIMETHYLAMMONIUM BROMIDE IN WATER, FORMAMIDE, AND GLYCEROL [J].