G-PROTEINS AND REGULATION OF ADENYLATE-CYCLASE (NOBEL LECTURE)

被引：26

作者：

GILMAN, AG

机构：

[1] Department of Pharmacology, University of Texas Southwestern, Medical Center at Dallas, Dallas, Texas

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 1995年 / 34卷 / 13-14期

关键词：

ADENYLATE CYCLASES; G PROTEINS; NOBEL LECTURE;

D O I：

10.1002/anie.199514061

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

How is the hormone‐activated synthesis of the second messenger cyclic AMP regulated? Or, in more general terms, how does the interaction of an extracellular agonist with a receptor lead to intracellular enzyme activity when receptor and enzyme are not distinct macromolecules? The mediators are membrane‐bound, guanine nucleotide binding regulatory proteins (G proteins). When the receptor is activated, G proteins dissociate into their subunits. These in turn activate or inhibit enzymes such as adenylate cyclases, which catalyze the synthesis of cyclic AMP. In these signal transmission processes G proteins act as molecular switches and amplifiers. Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：1406 / 1419

页数：14

共 154 条

[41] ADENYLATE-CYCLASE PERMANENTLY UNCOUPLED FROM HORMONE RECEPTORS IN A NOVEL VARIANT OF S49 MOUSE LYMPHOMA-CELLS [J].