FURTHER STUDIES ON GAMMAG-HEAVY CHAIN GENE COMPLEXES WITH PARTICULAR REFERENCE TO GENETIC MARKERS GM(G) AND GM(N)

The Gm antigens represent genetic markers for the heavy chains of γG-globulin and are distributed within three out of the four heavy chain subgroups (see references 1-4). These subgroups of heavy chains show distinct antigenic, physiochemical and structural differences indicating that they axe controlled by genes at different cistrons (4-7). Previous studies have dealt primarily with the heavy chains of the γG1-subgroup, and the corresponding main γG1-genes, Gmza and Gmfy, and in Mongoloids, Gmfya (8, 9). Furthermore, the various Gin(b) antigens of the γG3-subgroup have been studied in detail (10-12). Recently two new antigens were characterized, Gin(g) (13, 14) of the γG3- and Gin(n) (15) of the γG2-subgroup, which have proven of particular utility for understanding the relationship between the different cistrons involved in γG-heavy chain synthesis. © 1968, Rockefeller University Press., All rights reserved.