LOCALIZATION OF THE GENE ENCODING THE ALPHA-SUBUNIT OF HUMAN INTERLEUKIN-5 RECEPTOR (IL5RA) TO CHROMOSOME REGION 3P24-3P26

被引：19

作者：

ISOBE, M ^{[1
]}

KUMURA, Y ^{[1
]}

MURATA, Y ^{[1
]}

TAKAKI, S ^{[1
]}

TOMINAGA, A ^{[1
]}

TAKATSU, K ^{[1
]}

OGITA, Z ^{[1
]}

机构：

[1] KUMAMOTO UNIV,SCH MED,INST MED IMMUNOL,DEPT BIOL,KUMAMOTO 860,JAPAN

来源：

GENOMICS | 1992年 / 14卷 / 03期

基金：

日本科学技术振兴机构;

关键词：

D O I：

10.1016/S0888-7543(05)80180-6

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The chromosomal location of the human gene for the α subunit of interleukin-5 receptor (IL5RA) has been determined. The human IL5RA gene was localized to the short arm of chromosome 3 by Southern blot analysis of DNA from a panel of mouse-human hybrid somatic cell lines. The IL5RA gene has been further localized to human chromosome region 3p24-ep26 by in situ hybridization of a molecularly cloned IL5RA cDNA fragment to metaphase chromosomes. The results suggest that the IL5RA locus is unlinked to other members of the hematopoietic receptor family. Assignment of the IL5RA gene to chromosome 3 at bands p26-p24 raises the possibility that it may be altered by certain nonrandom chromosomal abnormalities arising in human hematopoietic malignancies and solid tumors. © 1992 Academic Press, Inc. All rights reserved.

引用

页码：755 / 758

页数：4

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