TRANSFERRIN SYNTHESIS BY MACROPHAGES - UP-REGULATION BY GAMMA-INTERFERON AND EFFECT ON LYMPHOCYTE-PROLIFERATION

被引：2

作者：

DJEHA, A ^{[1
]}

PEREZARELLANO, JL ^{[1
]}

HAYES, SL ^{[1
]}

BROCK, JH ^{[1
]}

机构：

[1] UNIV SALAMANCA,FAC MED,DEPT MED,SALAMANCA,SPAIN

来源：

FEMS MICROBIOLOGY IMMUNOLOGY | 1992年 / 105卷 / 5-6期

基金：

英国惠康基金;

关键词：

TRANSFERRIN SYNTHESIS; IRON; GAMMA-INTERFERON; MOUSE MACROPHAGE; LYMPHOCYTE PROLIFERATION;

D O I：

10.1111/j.1574-6968.1992.tb05912.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have investigated transferrin synthesis by human and mouse lymphoid and myeloid cells. It was found that transferrin synthesis is a property of mouse but not human macrophages, whereas in man T lymphocytes synthesised transferrin. Synthesis by mouse macrophages showed a dose-dependent increase in response to gamma-interferon (gamma-IFN), but iron added as ferric nitrilotriacetate had no effect. Macrophage-derived transferrin was found to contain iron already bound to it and was able to support Con A-stimulated mouse lymphocyte proliferation.

引用

页码：279 / 282

页数：4

共 9 条

[1] THE ROLE OF IRON AND TRANSFERRIN IN LYMPHOCYTE-TRANSFORMATION [J].