NIZATIDINE IN THE TREATMENT OF REFLUX ESOPHAGITIS - AN ITALIAN MULTICENTER STUDY

被引:4
作者
BALDI, F
LONGANESI, A
FERRARINI, F
MORSELLILABATE, AM
VOI, M
CAMARRI, F
PORRO, GB
TITTOBELLO, A
DOBRILLA, G
ANGELINI, G
CELLE, G
MAZZEO, F
BEDOGNI, V
MATTIOLI, S
ANGELETTI, CA
CORAZZIARI, E
CIPOLLETTA, L
SABBATINI, F
FAMILIARI, F
FERRAU, O
PUSTORINO, S
LICATA, A
RUSSO, A
机构
[1] Department of Internal Medicine and Gastroenterology, Policlinico S. Orsola, Bologna
[2] Medical Department of Eli Lilly Italia, Sesto Fiorentino
关键词
EROSIVE ESOPHAGITIS; MEDICAL TREATMENT; SYMPTOMATIC RELIEF; NIZATIDINE; ENDOSCOPIC HEALING;
D O I
10.1097/00042737-199306000-00015
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
objective: To evaluate the various doses and administration schedules of nizatidine in the treatment of reflux oesophagitis. Design and methods: Two hundred and forty patients with erosive-ulcerative oesophagitis were randomly allocated to a 6-week treatment regimen with nizatidine 150 mg three times daily (group A, n = 79), 150 + 150 + 300 mg (group B, n = 79) and 300 mg twice daily (group C, n = 82). Clinical evaluation was performed at entry and after 3 and 6 weeks, whereas endoscopy and laboratory tests were performed only at entry and at the end of the study. Results: Reflux symptoms were significantly reduced in all three groups after 6 weeks. The patients on three times daily regimens (groups A and B) improved some of their symptoms faster than those in group C. Oesophagitis healed with similar frequency in the three groups (A = 81.1%, B = 79.2% and C = 67.6%). Adverse events were rare and mild. Conclusions: High-dose nizatidine is safe and effective in relieving the symptoms and healing the lesions of oesophagitis.
引用
收藏
页码:475 / 478
页数:4
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