SYNTHESIS OF POTENTIAL INHIBITORS OF THE GLYCOSPHINGOLIPID BIOSYNTHESIS

被引：27

作者：

BRENNERWEISS, G ^{[1
]}

GIANNIS, A ^{[1
]}

SANDHOFF, K ^{[1
]}

机构：

[1] UNIV BONN,INST ORGAN CHEM & BIOCHEM,GERHARD DOMAGK STR 1,W-5300 BONN 1,GERMANY

来源：

TETRAHEDRON | 1992年 / 48卷 / 28期

关键词：

D O I：

10.1016/S0040-4020(01)90177-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of ceramide analogs 6 and 7 is reported here starting from L-cysteine. Alkylation of 2 and subsequent reduction of the intermediate formed ketone 3 afforded the diastereomeric alcohols 4. Deprotection and acylation of 4 lead to the desired product 6 which is converted to the sulfonium salt 7. Compound 6 is a powerful inhibitor of the glycosphingolipid biosynthesis.

引用

页码：5855 / 5860

页数：6

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