THE ROLE OF FREE-RADICALS AND NEUTROPHIL ELASTASE IN DEVELOPMENT OF PULMONARY-EMPHYSEMA

被引：16

作者：

KANAZAWA, H

KURIHARA, N

HIRATA, K

FUJIMOTO, S

TAKEDA, T

机构：

[1] First Department of Internal Medicine, Osaka City University Medical School, Osaka

来源：

INTERNAL MEDICINE | 1992年 / 31卷 / 07期

关键词：

SUPEROXIDE ANION; POLYMORPHONUCLEAR LEUKOCYTES (PMNS);

D O I：

10.2169/internalmedicine.31.857

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Extracellular proteolysis is hypothesized to be the major cause of pulmonary emphysema and oxygen-derived free radicals and neutrophil elastase are thought to play an important role in its pathogenesis. In this study, peripheral polymorphonuclear leukocytes (PMNs) obtained from 16 patients with emphysema generated a significantly larger amount of superoxide and elastase activity than those obtained from normal controls. A significant correlation was observed between elastase activity and superoxide release. In addition, the superoxide release showed a negative correlation with the disease duration. The superoxide release appeared to correlated with a decline of FEV1.0 over the course of several years in 8 patients. It seems likely that activated PMNs play an important role in the development of pulmonary emphysema.

引用

页码：857 / 860

页数：4

共 21 条

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