THE LIGAND-BINDING DOMAIN OF RHODOPSIN AND OTHER G-PROTEIN-LINKED RECEPTORS

被引:66
作者
OPRIAN, DD
机构
[1] Graduate Department of Biochemistry, Brandeis University, Waltham, 02254, Massachusetts
关键词
VISUAL PIGMENTS; BACTERIORHODOPSIN; RETINAL; AGONIST; ANTAGONIST;
D O I
10.1007/BF00762679
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Rhodopsin is a member of the very large family of G protein-linked receptors. The members of this family show clear signs of evolutionary relatedness, primarily in amino acid sequence homology, topographical structure of the proteins in the membrane, and the fact that all of the receptors function through the intermediary action of a GTP-binding regulatory protein or G protein. Recently, it has become clear that the structural similarity of these receptors extends well beyond the rather crude comparison of membrane topography. Reviewed here are several studies in which site-directed mutagenesis and active-site-directed reagents were used to show that the ligand-binding pockets of these receptors are highly similar. They are similar despite the fact that the structures of their various ligands are very different.
引用
收藏
页码:211 / 217
页数:7
相关论文
共 61 条
[1]   SITE OF ATTACHMENT OF RETINAL IN BACTERIORHODOPSIN [J].
BAYLEY, H ;
HUANG, KS ;
RADHAKRISHNAN, R ;
ROSS, AH ;
TAKAGAKI, Y ;
KHORANA, HG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (04) :2225-2229
[2]   CLONING AND STRUCTURE-FUNCTION OF THE H-2 HISTAMINE-RECEPTOR [J].
BIRDSALL, NJM .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (01) :9-10
[3]   SITE OF ATTACHMENT OF RETINAL IN RHODOPSIN [J].
BOWNDS, D .
NATURE, 1967, 216 (5121) :1178-&
[4]   CLONING AND EXPRESSION OF A RAT D2 DOPAMINE RECEPTOR CDNA [J].
BUNZOW, JR ;
VANTOL, HHM ;
GRANDY, DK ;
ALBERT, P ;
SALON, J ;
CHRISTIE, MJ ;
MACHIDA, CA ;
NEVE, KA ;
CIVELLI, O .
NATURE, 1988, 336 (6201) :783-787
[5]  
CHAZENBALK GD, 1990, J BIOL CHEM, V265, P20970
[6]   MOLECULAR-CLONING AND EXPRESSION OF THE CDNA FOR THE HAMSTER ALPHA-1-ADRENERGIC RECEPTOR [J].
COTECCHIA, S ;
SCHWINN, DA ;
RANDALL, RR ;
LEFKOWITZ, RJ ;
CARON, MG ;
KOBILKA, BK .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (19) :7159-7163
[7]   AN OPSIN GENE EXPRESSED IN ONLY ONE PHOTORECEPTOR CELL TYPE OF THE DROSOPHILA EYE [J].
COWMAN, AF ;
ZUKER, CS ;
RUBIN, GM .
CELL, 1986, 44 (05) :705-710
[8]   CLONING OF THE GENE AND CDNA FOR MAMMALIAN BETA-ADRENERGIC-RECEPTOR AND HOMOLOGY WITH RHODOPSIN [J].
DIXON, RAF ;
KOBILKA, BK ;
STRADER, DJ ;
BENOVIC, JL ;
DOHLMAN, HG ;
FRIELLE, T ;
BOLANOWSKI, MA ;
BENNETT, CD ;
RANDS, E ;
DIEHL, RE ;
MUMFORD, RA ;
SLATER, EE ;
SIGAL, IS ;
CARON, MG ;
LEFKOWITZ, RJ ;
STRADER, CD .
NATURE, 1986, 321 (6065) :75-79
[9]   STRUCTURAL FEATURES REQUIRED FOR LIGAND-BINDING TO THE BETA-ADRENERGIC-RECEPTOR [J].
DIXON, RAF ;
SIGAL, IS ;
CANDELORE, MR ;
REGISTER, RB ;
SCATTERGOOD, W ;
RANDS, E ;
STRADER, CD .
EMBO JOURNAL, 1987, 6 (11) :3269-3275
[10]   A FAMILY OF RECEPTORS COUPLED TO GUANINE-NUCLEOTIDE REGULATORY PROTEINS [J].
DOHLMAN, HG ;
CARON, MG ;
LEFKOWITZ, RJ .
BIOCHEMISTRY, 1987, 26 (10) :2657-2664