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PRESYNAPTIC AND POSTSYNAPTIC NEUROTOXIC EFFECTS OF DOPAMINE DEMONSTRATED BY INTRASTRIATAL INJECTION
被引:191
作者
:
FILLOUX, F
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV UTAH,SCH MED,DEPT PEDIAT,SALT LAKE CITY,UT 84132
FILLOUX, F
TOWNSEND, JJ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV UTAH,SCH MED,DEPT PEDIAT,SALT LAKE CITY,UT 84132
TOWNSEND, JJ
机构
:
[1]
UNIV UTAH,SCH MED,DEPT PEDIAT,SALT LAKE CITY,UT 84132
[2]
UNIV UTAH,SCH MED,DEPT PSYCHIAT,SALT LAKE CITY,UT 84132
[3]
UNIV UTAH,SCH MED,DEPT PATHOL,SALT LAKE CITY,UT 84132
来源
:
EXPERIMENTAL NEUROLOGY
|
1993年
/ 119卷
/ 01期
关键词
:
D O I
:
10.1006/exnr.1993.1008
中图分类号
:
Q189 [神经科学];
学科分类号
:
071006 ;
摘要
:
Considerable evidence indicates that dopamine (DA) may play a neurotoxic role in brain in certain pathologic circumstances. To investigate this issue, dopamine (1000 nmol/1 μl) was directly injected into the striatum of anesthetized Sprague-Dawley rats. Control animals received equal-volume injections of γ-aminobutyric acid (GABA) or NaCl at identical concentrations (diluted in distilled H2O, pH 7.0-7.7). Brains were removed 7 to 9 days later and frozen or fixed and sectioned for histologic and autoradiographic analysis. Dopamine injection resulted in a small-volume (3.3-mm3) lesion in comparison to control GABA and NaCl injections which produced only a needle track <0.6 mm3 in volume (P < 0.01). Dose dependency of DA toxicity was demonstrated, with substantial parenchymal damage requiring an injection of 500 nmol/1 μl. Within the lesion, marked neuronal loss, macrophage invasion, and capillary and glial proliferation were present. Acetylcholinesterase staining and D1 receptor binding were markedly reduced as well. [3H]RO5-4864 binding to peripheral benzodiazepine receptors (on astrocytes) was increased in the periphery of the lesion. The binding of 1-[3H]benzo[b]cyclohexylthiophenylpiperidine to dopamine uptake sites was also reduced, but over a wider striatal area in comparison to local parenchymal damage. Prior interruption of the dopaminergic nigrostriatal pathway (by injection of 6-hydroxydopamine) appeared to potentiate the toxicity of intrastriatal dopamine injection. The findings indicate that local injection of dopamine produces both post- and presynaptic damage to nigrostriatal structures, and support the contention that dopamine may act as a low-potency neurotoxin. © 1993 by Academic Press, Inc.
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页码:79 / 88
页数:10
相关论文
共 53 条
[1]
EFFECTS OF HYPOXIA ON THE ACTIVITY OF THE DOPAMINERGIC NEURON SYSTEM IN THE RAT STRIATUM AS STUDIED BY INVIVO BRAIN MICRODIALYSIS
AKIYAMA, Y
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
AKIYAMA, Y
KOSHIMURA, K
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
KOSHIMURA, K
OHUE, T
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
OHUE, T
LEE, K
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
LEE, K
MIWA, S
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
MIWA, S
YAMAGATA, S
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
YAMAGATA, S
KIKUCHI, H
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
KIKUCHI, H
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BAKER, AJ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO,DEPT ANESTHESIOL,LA JOLLA,CA 92093
BAKER, AJ
ZORNOW, MH
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO,DEPT ANESTHESIOL,LA JOLLA,CA 92093
ZORNOW, MH
SCHELLER, MS
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO,DEPT ANESTHESIOL,LA JOLLA,CA 92093
SCHELLER, MS
YAKSH, TL
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO,DEPT ANESTHESIOL,LA JOLLA,CA 92093
YAKSH, TL
SKILLING, SR
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO,DEPT ANESTHESIOL,LA JOLLA,CA 92093
SKILLING, SR
SMULLIN, DH
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO,DEPT ANESTHESIOL,LA JOLLA,CA 92093
SMULLIN, DH
LARSON, AA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO,DEPT ANESTHESIOL,LA JOLLA,CA 92093
LARSON, AA
KUCZENSKI, R
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO,DEPT ANESTHESIOL,LA JOLLA,CA 92093
KUCZENSKI, R
[J].
JOURNAL OF NEUROCHEMISTRY,
1991,
57
(04)
: 1370
-
1379
[3]
DIFFERENTIAL SPARING OF SOMATOSTATIN-NEUROPEPTIDE-Y AND CHOLINERGIC NEURONS FOLLOWING STRIATAL EXCITOTOXIN LESIONS
BEAL, MF
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,BOSTON,MA 02115
BEAL, MF
KOWALL, NW
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,BOSTON,MA 02115
KOWALL, NW
SWARTZ, KJ
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,BOSTON,MA 02115
SWARTZ, KJ
FERRANTE, RJ
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,BOSTON,MA 02115
FERRANTE, RJ
MARTIN, JB
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,BOSTON,MA 02115
MARTIN, JB
[J].
SYNAPSE,
1989,
3
(01)
: 38
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47
[4]
PERIPHERAL TYPE BENZODIAZEPINE BINDING-SITES ARE A SENSITIVE INDIRECT INDEX OF NEURONAL DAMAGE
BENAVIDES, J
论文数:
0
引用数:
0
h-index:
0
机构:
SYNTHELABO,ETUDES & RECH LAB,BIOCHEM PHARMACOL GRP,F-92220 BAGNEUX,FRANCE
SYNTHELABO,ETUDES & RECH LAB,BIOCHEM PHARMACOL GRP,F-92220 BAGNEUX,FRANCE
BENAVIDES, J
FAGE, D
论文数:
0
引用数:
0
h-index:
0
机构:
SYNTHELABO,ETUDES & RECH LAB,BIOCHEM PHARMACOL GRP,F-92220 BAGNEUX,FRANCE
SYNTHELABO,ETUDES & RECH LAB,BIOCHEM PHARMACOL GRP,F-92220 BAGNEUX,FRANCE
FAGE, D
CARTER, C
论文数:
0
引用数:
0
h-index:
0
机构:
SYNTHELABO,ETUDES & RECH LAB,BIOCHEM PHARMACOL GRP,F-92220 BAGNEUX,FRANCE
SYNTHELABO,ETUDES & RECH LAB,BIOCHEM PHARMACOL GRP,F-92220 BAGNEUX,FRANCE
CARTER, C
SCATTON, B
论文数:
0
引用数:
0
h-index:
0
机构:
SYNTHELABO,ETUDES & RECH LAB,BIOCHEM PHARMACOL GRP,F-92220 BAGNEUX,FRANCE
SYNTHELABO,ETUDES & RECH LAB,BIOCHEM PHARMACOL GRP,F-92220 BAGNEUX,FRANCE
SCATTON, B
[J].
BRAIN RESEARCH,
1987,
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(1-2)
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172
[5]
DIFFERENTIAL SENSITIVITY OF NEUROPEPTIDE-Y, SOMATOSTATIN AND NADPH-DIAPHORASE CONTAINING NEURONS IN RAT CORTEX AND STRIATUM TO QUINOLINIC ACID
BOEGMAN, RJ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV LAVAL,DEPT ANAT,QUEBEC CITY G1K 7P4,QUEBEC,CANADA
BOEGMAN, RJ
PARENT, A
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV LAVAL,DEPT ANAT,QUEBEC CITY G1K 7P4,QUEBEC,CANADA
PARENT, A
[J].
BRAIN RESEARCH,
1988,
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INTRASTRIATAL SPREADING OF BIOGENIC AMINES
BONDAREFF, W
论文数:
0
引用数:
0
h-index:
0
BONDAREFF, W
ROUTTENBERG, A
论文数:
0
引用数:
0
h-index:
0
ROUTTENBERG, A
NAROTZKY, R
论文数:
0
引用数:
0
h-index:
0
NAROTZKY, R
MCLONE, DG
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0
引用数:
0
h-index:
0
MCLONE, DG
[J].
EXPERIMENTAL NEUROLOGY,
1970,
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+
[7]
EXCITOTOXICITY OF NMDA AND KAINIC ACID IS MODULATED BY NIGROSTRIATAL DOPAMINERGIC FIBERS
CHAPMAN, AG
论文数:
0
引用数:
0
h-index:
0
CHAPMAN, AG
DURMULLER, N
论文数:
0
引用数:
0
h-index:
0
DURMULLER, N
LEES, GJ
论文数:
0
引用数:
0
h-index:
0
LEES, GJ
MELDRUM, BS
论文数:
0
引用数:
0
h-index:
0
MELDRUM, BS
[J].
NEUROSCIENCE LETTERS,
1989,
107
(1-3)
: 256
-
260
[8]
GLUTAMATE NEUROTOXICITY AND DISEASES OF THE NERVOUS-SYSTEM
CHOI, DW
论文数:
0
引用数:
0
h-index:
0
CHOI, DW
[J].
NEURON,
1988,
1
(08)
: 623
-
634
[9]
Cohen G, 1983, J Neural Transm Suppl, V19, P89
[10]
COHEN G, 1974, J BIOL CHEM, V249, P2447
←
1
2
3
4
5
6
→
共 53 条
[1]
EFFECTS OF HYPOXIA ON THE ACTIVITY OF THE DOPAMINERGIC NEURON SYSTEM IN THE RAT STRIATUM AS STUDIED BY INVIVO BRAIN MICRODIALYSIS
AKIYAMA, Y
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
AKIYAMA, Y
KOSHIMURA, K
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
KOSHIMURA, K
OHUE, T
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
OHUE, T
LEE, K
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
LEE, K
MIWA, S
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
MIWA, S
YAMAGATA, S
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
YAMAGATA, S
KIKUCHI, H
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
KYOTO UNIV,FAC MED,DEPT PHARMACOL,KYOTO 606,JAPAN
KIKUCHI, H
[J].
JOURNAL OF NEUROCHEMISTRY,
1991,
57
(03)
: 997
-
1002
[2]
CHANGES IN EXTRACELLULAR CONCENTRATIONS OF GLUTAMATE, ASPARTATE, GLYCINE, DOPAMINE, SEROTONIN, AND DOPAMINE METABOLITES AFTER TRANSIENT GLOBAL-ISCHEMIA IN THE RABBIT BRAIN
BAKER, AJ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO,DEPT ANESTHESIOL,LA JOLLA,CA 92093
BAKER, AJ
ZORNOW, MH
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO,DEPT ANESTHESIOL,LA JOLLA,CA 92093
ZORNOW, MH
SCHELLER, MS
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO,DEPT ANESTHESIOL,LA JOLLA,CA 92093
SCHELLER, MS
YAKSH, TL
论文数:
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引用数:
0
h-index:
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机构:
UNIV CALIF SAN DIEGO,DEPT ANESTHESIOL,LA JOLLA,CA 92093
YAKSH, TL
SKILLING, SR
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO,DEPT ANESTHESIOL,LA JOLLA,CA 92093
SKILLING, SR
SMULLIN, DH
论文数:
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引用数:
0
h-index:
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机构:
UNIV CALIF SAN DIEGO,DEPT ANESTHESIOL,LA JOLLA,CA 92093
SMULLIN, DH
LARSON, AA
论文数:
0
引用数:
0
h-index:
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机构:
UNIV CALIF SAN DIEGO,DEPT ANESTHESIOL,LA JOLLA,CA 92093
LARSON, AA
KUCZENSKI, R
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO,DEPT ANESTHESIOL,LA JOLLA,CA 92093
KUCZENSKI, R
[J].
JOURNAL OF NEUROCHEMISTRY,
1991,
57
(04)
: 1370
-
1379
[3]
DIFFERENTIAL SPARING OF SOMATOSTATIN-NEUROPEPTIDE-Y AND CHOLINERGIC NEURONS FOLLOWING STRIATAL EXCITOTOXIN LESIONS
BEAL, MF
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,BOSTON,MA 02115
BEAL, MF
KOWALL, NW
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,BOSTON,MA 02115
KOWALL, NW
SWARTZ, KJ
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,BOSTON,MA 02115
SWARTZ, KJ
FERRANTE, RJ
论文数:
0
引用数:
0
h-index:
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机构:
HARVARD UNIV,SCH MED,BOSTON,MA 02115
FERRANTE, RJ
MARTIN, JB
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV,SCH MED,BOSTON,MA 02115
MARTIN, JB
[J].
SYNAPSE,
1989,
3
(01)
: 38
-
47
[4]
PERIPHERAL TYPE BENZODIAZEPINE BINDING-SITES ARE A SENSITIVE INDIRECT INDEX OF NEURONAL DAMAGE
BENAVIDES, J
论文数:
0
引用数:
0
h-index:
0
机构:
SYNTHELABO,ETUDES & RECH LAB,BIOCHEM PHARMACOL GRP,F-92220 BAGNEUX,FRANCE
SYNTHELABO,ETUDES & RECH LAB,BIOCHEM PHARMACOL GRP,F-92220 BAGNEUX,FRANCE
BENAVIDES, J
FAGE, D
论文数:
0
引用数:
0
h-index:
0
机构:
SYNTHELABO,ETUDES & RECH LAB,BIOCHEM PHARMACOL GRP,F-92220 BAGNEUX,FRANCE
SYNTHELABO,ETUDES & RECH LAB,BIOCHEM PHARMACOL GRP,F-92220 BAGNEUX,FRANCE
FAGE, D
CARTER, C
论文数:
0
引用数:
0
h-index:
0
机构:
SYNTHELABO,ETUDES & RECH LAB,BIOCHEM PHARMACOL GRP,F-92220 BAGNEUX,FRANCE
SYNTHELABO,ETUDES & RECH LAB,BIOCHEM PHARMACOL GRP,F-92220 BAGNEUX,FRANCE
CARTER, C
SCATTON, B
论文数:
0
引用数:
0
h-index:
0
机构:
SYNTHELABO,ETUDES & RECH LAB,BIOCHEM PHARMACOL GRP,F-92220 BAGNEUX,FRANCE
SYNTHELABO,ETUDES & RECH LAB,BIOCHEM PHARMACOL GRP,F-92220 BAGNEUX,FRANCE
SCATTON, B
[J].
BRAIN RESEARCH,
1987,
421
(1-2)
: 167
-
172
[5]
DIFFERENTIAL SENSITIVITY OF NEUROPEPTIDE-Y, SOMATOSTATIN AND NADPH-DIAPHORASE CONTAINING NEURONS IN RAT CORTEX AND STRIATUM TO QUINOLINIC ACID
BOEGMAN, RJ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV LAVAL,DEPT ANAT,QUEBEC CITY G1K 7P4,QUEBEC,CANADA
BOEGMAN, RJ
PARENT, A
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV LAVAL,DEPT ANAT,QUEBEC CITY G1K 7P4,QUEBEC,CANADA
PARENT, A
[J].
BRAIN RESEARCH,
1988,
445
(02)
: 358
-
362
[6]
INTRASTRIATAL SPREADING OF BIOGENIC AMINES
BONDAREFF, W
论文数:
0
引用数:
0
h-index:
0
BONDAREFF, W
ROUTTENBERG, A
论文数:
0
引用数:
0
h-index:
0
ROUTTENBERG, A
NAROTZKY, R
论文数:
0
引用数:
0
h-index:
0
NAROTZKY, R
MCLONE, DG
论文数:
0
引用数:
0
h-index:
0
MCLONE, DG
[J].
EXPERIMENTAL NEUROLOGY,
1970,
28
(02)
: 213
-
+
[7]
EXCITOTOXICITY OF NMDA AND KAINIC ACID IS MODULATED BY NIGROSTRIATAL DOPAMINERGIC FIBERS
CHAPMAN, AG
论文数:
0
引用数:
0
h-index:
0
CHAPMAN, AG
DURMULLER, N
论文数:
0
引用数:
0
h-index:
0
DURMULLER, N
LEES, GJ
论文数:
0
引用数:
0
h-index:
0
LEES, GJ
MELDRUM, BS
论文数:
0
引用数:
0
h-index:
0
MELDRUM, BS
[J].
NEUROSCIENCE LETTERS,
1989,
107
(1-3)
: 256
-
260
[8]
GLUTAMATE NEUROTOXICITY AND DISEASES OF THE NERVOUS-SYSTEM
CHOI, DW
论文数:
0
引用数:
0
h-index:
0
CHOI, DW
[J].
NEURON,
1988,
1
(08)
: 623
-
634
[9]
Cohen G, 1983, J Neural Transm Suppl, V19, P89
[10]
COHEN G, 1974, J BIOL CHEM, V249, P2447
←
1
2
3
4
5
6
→