CYTOTOXICITY OF A TRANSFERRIN-ADRIAMYCIN CONJUGATE TO ANTHRACYCLINE-RESISTANT CELLS

被引：39

作者：

FRITZER, M

BARABAS, K

SZUTS, V

BERCZI, A

SZEKERES, T

FAULK, WP

GOLDENBERG, H

机构：

[1] UNIV VIENNA,INST MED CHEM,WAEHRINGERSTR 10,A-1090 VIENNA,AUSTRIA

[2] HUNGARIAN ACAD SCI,BIOL RES CTR,INST BIOPHYS,H-6701 SZEGED,HUNGARY

[3] METHODIST HOSP INDIANA,CTR REPROD & TRANSPLANTAT IMMUNOL,INDIANAPOLIS,IN 46202

来源：

INTERNATIONAL JOURNAL OF CANCER | 1992年 / 52卷 / 04期

关键词：

D O I：

10.1002/ijc.2910520421

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Conjugates of adriamycin coupled to transferrin by glutaraldehyde are cytotoxic to human promyelocytic (HL-60) and erythroleukemic (K562) cells. Growth inhibition of adriamycin-sensitive cells, as evaluated by thymidine incorporation and the MTT-assay, was higher for conjugates than for free adriamycin. The cytotoxicity toward adriamycin-resistant K562 and HL-60 cells was 3-fold and more than 10-fold higher, respectively, for the transferrin-adriamycin conjugate than for the free drug. The effect of the conjugate was dependent on its adriamycin content, i.e., on its conjugation number.

引用

页码：619 / 623

页数：5

共 34 条

[1] EVIDENCE IN SUPPORT OF THE PLASMA-MEMBRANE AS THE TARGET FOR TRANSFERRIN-ADRIAMYCIN CONJUGATES IN K562 CELLS [J].