EXPRESSION OF A CALCIUM-BINDING PROTEIN PEL98 (MTS1) DURING DIFFERENTIATION OF HUMAN PROMYELOCYTIC LEUKEMIA HL-60 CELLS

被引：32

作者：

TAKENAGA, K ^{[1
]}

NAKAMURA, Y ^{[1
]}

SAKIYAMA, S ^{[1
]}

机构：

[1] CHIBA CANC CTR,RES INST,DIV BIOCHEM,CHUOH KU,CHIBA 260,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 202卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.1898

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The expression of pEL98 (also termed mts1), an S100-related calcium-binding protein, was induced during macrophagic or granulocytic differentiation of human promyelocytic leukemia HL-60 cells in response to phorbol. 12-myristate 13-acetate or dimethylsulfoxide, respectively. However, pEL98 expression remained at the low level during granulocytic differentiation of the cells by the treatment with all-trans retinoic acid. The expression of cell motility, but not adhesiveness or phagocytic ability, was found to be coincided with that of pEL98 (mts1), suggesting that pEL98 (mts1) is involved in regulating cell motility. Immunocytochemical analysis demonstrated that pEL98 (mts1) was expressed in human monocytes, macrophages and polymorphonuclear leukocytes. (C) 1994 Academic Press, Inc.

引用

页码：94 / 101

页数：8

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