EFFECTS OF INDOLE-3-ACETIC-ACID ON CROTON OIL-INDUCED AND ARACHIDONIC ACID-INDUCED MOUSE EAR EDEMA

被引:19
作者
JONES, LH
ABDALLA, DSP
FREITAS, JC
机构
[1] UNIV SAO PAULO, INST BIOSCI, DEPT PHYSIOL, BR-05508900 SAO PAULO, BRAZIL
[2] UNIV SAO PAULO, FAC PHARMACEUT SCI, DEPT CLIN & TOXICOL ANAL, BR-05508900 SAO PAULO, BRAZIL
关键词
INDOLE-3-ACETIC ACID; MOUSE EAR EDEMA; ANTIOXIDANTS; CROTON OIL; ARACHIDONIC ACID;
D O I
10.1007/BF01797863
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The indole-3-acetic acid (IAA) is a plant growth hormone (auxin) being considered as a tryptophan metabolite in animals. The main purpose of this work was to verify IAA's topical anti-inflammatory action using croton oil- or arachidonic acid-induced mouse ear edema, in comparison to known anti-inflammatory agents. IAA antioxidant activity was also verified by measuring the inhibition of brain homogenate lipid peroxidation with the thiobarbituric acid reactive substances (TEARS) test. IAA inhibited the action of both croton oil- and arachidonic acid-induced edema in a dose-dependent manner (4.0 mu moles IAA inhibited 75.8% in croton oil and 82.5% in arachidonic acid induced ear edema). Both IAA (5.3 mM) and indomethacin (8.0 mM) inhibited TEARS formation. Data suggest that IAA exhibits antiinflammatory effect possibly by its antioxidant activity.
引用
收藏
页码:372 / 375
页数:4
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