PHOTOCHEMICAL DECOMPOSITION OF ALKANNIN SHIKONIN ENANTIOMERS

被引：31

作者：

CHENG, HW ^{[1
]}

CHEN, FA ^{[1
]}

HSU, HC ^{[1
]}

CHEN, CY ^{[1
]}

机构：

[1] CHIA NAN JR COLL PHARM, TAINAN, TAIWAN

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 120卷 / 02期

关键词：

ALKANNIN SHIKONIN; PHOTOCHEMICAL DECOMPOSITION; MACROTOMIA EUCHROMA; PHOTODEGRADATION;

D O I：

10.1016/0378-5173(94)00367-E

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Alkannin/shikonin ((+/-)-5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentneyl)-1,4-napthoquinone), isolated from Macrotomia euchroma, is sensitive to light exposure. A chloroform solution of alkannin/shikonin was exposed to sunlight for 1 month. The major photolytic product, a newly discovered naphthoquinone derivative, was isolated by adsorption chromatography. The chemical structure of the purified photolytic product was identified by NMR, MS and FTIR techniques to be (-)-5,8-dihydroxy-2-(1-hydroxy-3-oxo-4-methyl-4-pentenyl)- 1,4-naphthoquinone, indicating that a photo-oxidation reaction had occurred.

引用

页码：137 / 144

页数：8

共 16 条

[1]

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[2]

COXON JM, 1974, ORG PHOTOCHEM, P154

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