Scientific Opinion on Arsenic in Food EFSA Panel on Contaminants in the Food Chain (CONTAM)

被引：431

作者：

Alexander, Jan ^{[1
]}

Benford, Diane ^{[1
]}

Boobis, Alan ^{[1
]}

Ceccatelli, Sandra ^{[1
]}

Cravedi, Jean-Pierre ^{[1
]}

Di Domenico, Alessandro ^{[1
]}

Doerge, Daniel ^{[1
]}

Dogliotti, Eugenia ^{[1
]}

Edler, Lutz ^{[1
]}

Farmer, Peter ^{[1
]}

Filipic, Metka ^{[1
]}

Fink-Gremmels, Johanna ^{[1
]}

Fuerst, Peter ^{[1
]}

Guerin, Thierry ^{[1
]}

Knutsen, Helle Katrine ^{[1
]}

Machala, Miroslav ^{[1
]}

Mutti, Antonio ^{[1
]}

Schlatter, Josef ^{[1
]}

van Leeuwen, Rolaf ^{[1
]}

Verger, Philippe ^{[1
]}

机构：

[1] EFSA, Parma, Italy

来源：

EFSA JOURNAL | 2009年 / 7卷 / 10期

关键词：

total arsenic; inorganic arsenic; organic arsenic; analysis; food; occurrence; dietary exposure; risk assessment; toxicity; bench mark dose (BMD); margin of exposure (MOE);

D O I：

10.2903/j.efsa.2009.1351

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) assessed the risks to human health related to the presence of arsenic in food. More than 100,000 occurrence data on arsenic in food were considered with approximately 98 % reported as total arsenic. Making a number of assumptions for the contribution of inorganic arsenic to total arsenic, the inorganic arsenic exposure from food and water across 19 European countries, using lower bound and upper bound concentrations, has been estimated to range from 0.13 to 0.56 mu g/kg bodyweight (b. w.) per day for average consumers, and from 0.37 to 1.22 mu g/kg b. w. per day for 95th percentile consumers. Dietary exposure to inorganic arsenic for children under three years of age is in general estimated to be from 2 to 3-fold that of adults. The CONTAM Panel concluded that the provisional tolerable weekly intake (PTWI) of 15 mu g/kg b. w. established by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) is no longer appropriate as data had shown that inorganic arsenic causes cancer of the lung and urinary bladder in addition to skin, and that a range of adverse effects had been reported at exposures lower than those reviewed by the JECFA. The CONTAM Panel modelled the dose-response data from key epidemiological studies and selected a benchmark response of 1 % extra risk. A range of benchmark dose lower confidence limit (BMDL01) values between 0.3 and 8 mu g/kg b.w. per day was identified for cancers of the lung, skin and bladder, as well as skin lesions. The estimated dietary exposures to inorganic arsenic for average and high level consumers in Europe are within the range of the BMDL01 values identified, and therefore there is little or no margin of exposure and the possibility of a risk to some consumers cannot be excluded.

引用

页数：199

共 599 条

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