REGULATION OF FOOD AND WATER INTAKE IN RATS AS RELATED TO PLASMA OSMOLARITY AND VOLUME

被引:64
作者
GUTMAN, Y
KRAUSZ, M
机构
[1] Department of Pharmacology, The Hebrew University-Hadassah Medical School, Jerusalem
关键词
Drinking; Eating; Food deprivation; Hypovolemia; Plasma osmolarity; Plasma volume; Water deprivation;
D O I
10.1016/0031-9384(69)90181-4
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Food intake was suppressed in rats by subcutaneous injection of hypertonic saline while intraperitoneal loading of isotonic saline increased food consumption. Hypovolemia induced by subcutaneous injection of polyethylene glycol (Carbowax, M-20), decreased food intake in rats considerably. Free access to water under food deprivation caused significant dilution of plasma while free access to food under water deprivation resulted in hypertonicity of plasma. Feeding schedules of 23 hr food and 1 hr water vs 23 hr water and 1 hr food, caused plasma osmolarity to change from 286 mOsm/kg to 318 mOsm/kg. These wide variations are discussed in relation to the interaction of plasma osmolarity with food and water intake. © 1969.
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页码:311 / &
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