INVIVO HYPERTHERMIA INDUCES EXPRESSION OF HSP70 MESSENGER-RNA IN BRAIN-REGIONS CONTROLLING THE NEUROENDOCRINE RESPONSE TO STRESS

被引：78

作者：

BLAKE, MJ ^{[1
]}

NOWAK, TS ^{[1
]}

HOLBROOK, NJ ^{[1
]}

机构：

[1] NINCDS,NEUROPATHOL & NEUROANAT SCI LAB,BETHESDA,MD 20205

来源：

MOLECULAR BRAIN RESEARCH | 1990年 / 8卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Heat; Hippocampus; HSP70; Hypothalamus; In situ hybridization; mRNA; Stress;

D O I：

10.1016/0169-328X(90)90014-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Regional localization of HSP70 expression in brain of rats exposed to increased ambient temperatures was examined using in situ hybridization. In addition to the cerebellar granule cell layer and choroid plexus, selective hybridization was observed in the hippocampal dentate gyrus, paraventricular and dorsomedial hypothalamic nuclei, median eminence, and medial habenula. Apparently, cells in brain regions coordinating the neuroendocrine response to stress show a preferential induction of cellular stress proteins in response to heat. © 1990.

引用

页码：89 / 92

页数：4

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