RANITIDINE INTERFERENCE WITH THE MONOCLONAL EMIT DAU AMPHETAMINE/METHAMPHETAMINE IMMUNOASSAY

被引：27

作者：

POKLIS, A ^{[1
]}

HALL, KV ^{[1
]}

STILL, J ^{[1
]}

BINDER, SR ^{[1
]}

机构：

[1] BIORAD LABS,CLIN HPLC GRP,HERCULES,CA 94547

来源：

JOURNAL OF ANALYTICAL TOXICOLOGY | 1991年 / 15卷 / 02期

关键词：

D O I：

10.1093/jat/15.2.101

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The interference of ranitidine with the monoclonal EMIT d.a.u. amphetamine/methamphetamine immunoassay (ME) was investigated. Urine specimens collected from 23 patients receiving 150-300 mg of ranitidine daily were found to contain 7-271 mg/L of the drug when analyzed by Remedi(TM) automated high pressure liquid chromatography. Only patient specimens and urine samples with ranitidine added at concentrations greater than 91 mg/L gave false positive ME results. Of the 63 patient urine samples analyzed by ME, 12 gave false positive results. All false positive results occurred in the first or second void after ingestion. No false positive results occurred with the polyclonal EMIT d.a.u. amphetamine or TDx amphetamine/methamphetamine ll assays.

引用

页码：101 / 103

页数：3

共 6 条

[1] TOXICOLOGICAL SCREENING BY LIQUID-CHROMATOGRAPHY [J].