THE SULFATE CONJUGATE OF DIFLUNISAL - ITS SYNTHESIS AND SYSTEMIC STABILITY IN THE RAT

被引：12

作者：

DICKINSON, RG ^{[1
]}

KING, AR ^{[1
]}

HANSENMOLLER, J ^{[1
]}

机构：

[1] ROYAL DANISH SCH PHARM,DEPT ORGAN CHEM,DK-2100 COPENHAGEN,DENMARK

来源：

XENOBIOTICA | 1991年 / 21卷 / 05期

基金：

英国医学研究理事会;

关键词：

D O I：

10.3109/00498259109039503

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Diflunisal (DF) is metabolized in rats and humans primarily to its acyl glucuronide, phenolic glucuronide and sulphate conjugates. 2. DF sulphate was synthesized and administered i.v. to conscious bile-exteriorized rats at 10 mg DF equiv./kg. 3. DF sulphate was excreted almost exclusively in urine, and its systemic hydrolysis, monitored by glucuronidation of liberated DF, was quantitatively negligible. 4. Systemic stability of DF sulphate was therefore similar to DF phenolic glucuronide, and contrasted with the systemic instability of DF acyl glucuronide.

引用

页码：635 / 640

页数：6

共 16 条

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