CALCIUM OSCILLATION ASSOCIATED WITH REDUCED PROTEIN-KINASE-C ACTIVITIES IN RAS-TRANSFORMED NIH3T3 CELLS

被引：22

作者：

FU, T

SUGIMOTO, Y

OKI, T

MURAKAMI, S

OKANO, Y

NOZAWA, Y

机构：

[1] GIFU UNIV,SCH MED,DEPT BIOCHEM,TSUKASAMACHI 40,GIFU 500,JAPAN

[2] INST PHYS & CHEM RES,TSUKUBA LIFE SCI CTR,AGING PROC RES LAB,FRONTIER RES PROGRAM,TSUKUBA,IBARAKI 305,JAPAN

来源：

FEBS LETTERS | 1991年 / 281卷 / 1-2期

关键词：

CA-2+ OSCILLATION; RAS-TRANSFORMED FIBROBLAST; PROTEIN KINASE-C;

D O I：

10.1016/0014-5793(91)80407-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We show here novel intracellular Ca2+ oscillation in v-K-ras-transformed NIH3T3 cells induced by mitogenic peptide hormones, bradykinin and bombesin, as well as fetal calf serum. Induction of the Ca2+ oscillation is strongly correlated with the malignant properties and inversely with PKC activities in vitro and in vivo. These results suggest that the mitogen-induced Ca2+ oscillation is negatively regulated by PKC, which modulates Ca2+ influx in v-K-ras-transformed NIH3T3 cells.

引用

页码：263 / 266

页数：4

共 31 条

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[2]

BERRIDGE MJ, 1990, BIOL MED SIGNAL TRAN, P108

[3]

BLACKSHEAR PJ, 1985, J BIOL CHEM, V260, P3304

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