INNATE RESISTANCE TO NEW ANTIMALARIAL-DRUGS IN PLASMODIUM-FALCIPARUM FROM NIGERIA

被引：41

作者：

ODUOLA, AMJ

SOWUNMI, A

MILHOUS, WK

KYLE, DE

MARTIN, RK

WALKER, O

SALAKO, LA

机构：

[1] WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307

[2] UNIV IBADAN,COLL MED,DEPT PHARMACOL & THERAPEUT,IBADAN,NIGERIA

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1992年 / 86卷 / 02期

关键词：

D O I：

10.1016/0035-9203(92)90533-I

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The rapid dissemination of chloroquine-resistant Plasmodium falciparum in West Africa has been well documented and represents a significant health threat to autochthonous populations. The methodical development of alternative chemotherapeutic agents demands that dispensing new antimalarial drugs (mefloquine, halofantrine, and artemisinin [qinghaosu]) be closely monitored in order to protect their clinical utility. Indeed, mefloquine-resistant strains of P. falciparum have been reported. We present data from experiments in vitro on the innate resistance of P. falciparum isolates to mefloquine as well as a disturbing observation of transient resistance to artemisinin. The implications for the extended efficacy of these new antimalarial drugs are addressed.

引用

页码：123 / 126

页数：4

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