CULTURED EPITHELIAL-CELLS FROM PATIENTS WITH CYSTIC-FIBROSIS HAVE AN INCREASED EXPRESSION OF THE 14-KDA CA-2+-BINDING PROTEIN CFA

被引：12

作者：

KEULEMANS, J

VANHEYNINGEN, V

SCHOLTE, BJ

BIJMAN, J

VANDERKAMP, AWM

KANSEN, M

DEJONGE, H

GALJAARD, H

HOOGEVEEN, AT

机构：

[1] ERASMUS UNIV,MGC,DEPT CELL BIOL & GENET,POB 1738,3000 DR ROTTERDAM,NETHERLANDS

[2] WESTERN GEN HOSP,MRC,HUMAN GENET UNIT,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND

[3] ERASMUS UNIV,DEPT BIOCHEM,3000 DR ROTTERDAM,NETHERLANDS

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 174卷 / 03期

关键词：

D O I：

10.1016/0006-291X(91)91560-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Cystic Fibrosis antigen (CFA) is a 14 kDa. Ca2+-binding protein known to be expressed in cells of myeloid origin during normal cell differentiation. CFA serum levels are elevated in Cystic Fibrosis (CF) patients and heterozygotes. We examined the expression of CFA in different cultured epithelial cells from controls and patients with CF. The steady state level of CFA was in general higher in epithelial cells from CF patients compared to control cells and was found to increase during cell aging. The latter difference could be attributed to an increased rate of CFA synthesis rather than to an impairment of CFA degradation or secretion, as shown by pulse chase experiments. © 1991.

引用

页码：1281 / 1286

页数：6

共 23 条

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