DETERMINATION OF ZOPICLONE ENANTIOMERS IN PLASMA BY LIQUID-CHROMATOGRAPHY USING A CHIRAL CELLULOSE CARBAMATE COLUMN

被引：32

作者：

FERNANDEZ, C

BAUNE, B

GIMENEZ, F

THUILLIER, A

FARINOTTI, R

机构：

[1] HOP LA PITIE SALPETRIERE,SERV PHARM,UNITE DOSAGE MEDICAMENTS,47 BLVD HOP,F-75013 PARIS,FRANCE

[2] UNIV PARIS 11,DEPT PHARM CLIN,F-92290 CHATENAY MALABRY,FRANCE

[3] HOP XAVIER BICHAT CLAUDE BERNARD,SERV PHARM CLIN & BIOMAT,F-75018 PARIS,FRANCE

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 572卷 / 1-2期

关键词：

D O I：

10.1016/0378-4347(91)80483-S

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The enantiomers of zopiclone were determined in human plasma using a sequential achiral-chiral liquid chromatographic method. Zopiclone was separated from the biological matrix and quantified on an achiral silica column. The limit of detection was 5 ng/ml. The eluent fraction containing zopiclone was collected, evaporated, reconstituted with the mobile phase and injected onto a chiral cellulose carbamate column where the enantiomeric ratio was calculated. This validated method, applied to a pilot study, suggests that pharmacokinetics of zopiclone is stereoselective.

引用

页码：195 / 202

页数：8

共 6 条

[1]

Gaillot J, 1982, Int Pharmacopsychiatry, V17 Suppl 2, P76

[2] ZOPICLONE - A REVIEW OF ITS PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES AND THERAPEUTIC EFFICACY AS AN HYPNOTIC [J].