TESTOSTERONE MODULATES MESOLIMBIC DOPAMINERGIC ACTIVITY IN MALE-RATS

被引：57

作者：

HERNANDEZ, L ^{[1
]}

GONZALEZ, L ^{[1
]}

MURZI, E ^{[1
]}

PAEZ, X ^{[1
]}

GOTTBERG, E ^{[1
]}

BAPTISTA, T ^{[1
]}

机构：

[1] UNIV LOS ANDES,PSYCHIAT UNIT,MERIDA,VENEZUELA

来源：

NEUROSCIENCE LETTERS | 1994年 / 171卷 / 1-2期

关键词：

DOPAMINE; PUBERTY; SCHIZOPHRENIA; MICRODIALYSIS; AMPHETAMINE; TESTOSTERONE;

D O I：

10.1016/0304-3940(94)90632-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Male rats were castrated before puberty. When they were adult, the activity of their mesolimbic dopamine system was tested by ventral striatum microdialysis. Amphetamine injections increased dopamine more in castrated rats than in normal rats. This exaggerated response was attenuated by testosterone replacement therapy. The mechanism by which androgens modulate the activity of the mesolimbic dopamine system is discussed.

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页码：172 / 174

页数：3

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