DIRECT ENANTIOMERIC SEPARATION OF FLAVANONES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY USING VARIOUS CHIRAL STATIONARY PHASES

被引：18

作者：

FICARRA, P

FICARRA, R

BERTUCCI, C

TOMMASINI, S

CALABRO, ML

COSTANTINO, D

CARULLI, M

机构：

[1] UNIV PISA,DEPT CHEM & IND CHEM,I-56126 PISA,ITALY

[2] UNIV REGGIO CALABRIA,FAC PHARM,I-88021 ROCCELLETTA BORGI,ITALY

来源：

PLANTA MEDICA | 1995年 / 61卷 / 02期

关键词：

COLUMN LIQUID CHROMATOGRAPHY; CHIRAL STATIONARY PHASES; FLAVANONES; ENANTIOMERIC SEPARATION; ELUTION ORDER; CIRCULAR DICHROISM DETECTION SYSTEM;

D O I：

10.1055/s-2006-958041

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The performance of four chiral liquid chromatographic columns (Chiralcel(R) OA, OJ, OC, OD) was studied with respect to the enantioseparation of flavanones and some derivatives. The effect of mobile phase composition on the retention time and stereoselectivity was studied. A good enantioseparation (a up to 1.45) was achieved for most of the racemates. Further, the elution order of the enantiomers from the chiral stationary phases has been determined by using a circular dichroism based detection system.

引用

页码：171 / 176

页数：6

共 22 条

[1]

BOHM BA, 1982, FLAVONOIDS ADV RES

[2] MEASUREMENT OF UNDERIVATISED METOPROLOL ENANTIOMERS IN HUMAN-PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH A CHIRAL STATIONARY PHASE [J].