SERUM HYALURONIC-ACID FOR THE ASSESSMENT OF GRAFT VIABILITY IN PORCINE LIVER-TRANSPLANTATION

被引：23

作者：

ITASAKA, H

KISHIKAWA, K

SUEHIRO, T

YANAGA, K

SHIMADA, M

HIGASHI, H

KAKIZOE, S

IKEDA, T

WAKIYAMA, S

SUGIMACHI, K

机构：

[1] Second Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, 812, 3-1-1 Maidashi, Higashi-ku

来源：

SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY | 1994年 / 24卷 / 08期

关键词：

HYALURONIC ACID; ENDOTHELIAL CELLS; LIVER TRANSPLANTATION; GRAFT VIABILITY;

D O I：

10.1007/BF01636778

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

For the assessment of graft viability, serum hyaluronic acid (HA) levels during porcine orthotopic liver transplantation were measured in two groups: group 1 (viable: n = 5) in which allografts were transplanted following a minimal cold (4-degrees-C) preservation, and group 2 (nonviable: n = 4) in which allografts were transplanted after cold static storage (4-degrees-C) for 24 h in University of Wisconsin solution. The changes in the HA levels reached a significant difference between the two groups at 30 min after reperfusion (P < 0.02). In group 1, all animals survived for over 4 days, while all animals in group 2 died within 24 h. The serum HA also demonstrated a significant correlation with prothrombin time, beta-glucuronidase, and aspartate aminotransferase at 120 min after reperfusion. These results suggest that the measurement of serum HA is a potentially effective index for evaluating hepatic allograft viability.

引用

页码：719 / 724

页数：6

共 24 条

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