EFFECTS OF SOME ORGANOTIN COMPOUNDS ON TISSUE AMINE LEVELS IN RATS

被引：33

作者：

ROBINSON, IM

机构：

[1] Division of Toxicological Evaluation, Food and Drug Administration, US Department of Health, Education, and Welfare, Washington, DC

来源：

FOOD AND COSMETICS TOXICOLOGY | 1969年 / 7卷 / 01期

关键词：

D O I：

10.1016/S0015-6264(69)80264-6

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Various organotin compounds were administered intraperitoneally to rats todetermine whether their toxicity might be related to tissue amine levels. Female Osborne-Mendel rats were given a lethal dose of triethyl-, tributyl- or dibutyltin or a non-lethal dose of tri- or dioctyltin. The noradrenaline and adrenaline levels in the brain, heart and adrenals and the 5-hydroxytryptamine level in brain were determined at varying intervals up to 48 hr after treatment. All of the compounds tested lowered brain and heart noradrenaline levels significantly between 2 and 48 hr, as well as brain 5-hydroxytryptamine between 24 and 48 hr. Heart adrenaline levels were increased by triethyl-, tributyl- and dibutyltin while adrenal adrenaline and noradrenaline levels were significantly reduced. The toxicity of these compounds appeared to parallel the release of catecholamines from the adrenals. © 1969 Pergamon Press Limited.

引用

页码：47 / &

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