PLASMA-CONCENTRATIONS OF BUPIVACAINE AFTER INTERCOSTAL NERVE BLOCK IN PATIENTS AFTER ORTHOTOPIC LIVER-TRANSPLANTATION

被引：10

作者：

BODENHAM, A ^{[1
]}

PARK, GR ^{[1
]}

机构：

[1] ADDENBROOKES HOSP,DEPT ANAESTHESIA,CAMBRIDGE CB2 2QQ,ENGLAND

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1990年 / 64卷 / 04期

关键词：

Anaesthetic techniques: intercostal; Anaesthetics local: bupivacaine; plasma concentration;

D O I：

10.1093/bja/64.4.436

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Summary: Bilateral intercostal nerve blocks were performed on 12 occasions in 11 patients after liver transplantation. Group 1 (six patients) received bupivacaine 2 mg kg-1 on one occasion; in group 2 (five patients) bupivacaine 2 mg kg-1 with adrenaline 1: 200000 was injected on two occasions separated by 6 h. Arterial blood was sampled repeatedly and analysed for total bupivacaine concentrations by high performance liquid chromatography (HPLC). Six patients had bupivacaine concentrations within the putative toxic threshold of 2-4 ug ml-1. The use of adrenaline-containing solutions neither slowed absorption reliably nor decreased peak concentrations of bupivacaine. Cumulation of bupivacaine occurred in group 2. No patient had adverse effects attributable to the bupivacaine. © 1990 British Journal of Anaesthesia.

引用

页码：436 / 441

页数：6

共 23 条

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