SYNTHESIS AND BIOLOGICAL EVALUATION OF CARBOCYCLIC ANALOGS OF RIBAVIRIN

被引：11

作者：

NOBLE, SA ^{[1
]}

BEDDALL, NE ^{[1
]}

BEVERIDGE, AJ ^{[1
]}

MARR, CLP ^{[1
]}

MO, CL ^{[1
]}

MYERS, PL ^{[1
]}

PENN, CR ^{[1
]}

STORER, R ^{[1
]}

WOODS, JM ^{[1
]}

机构：

[1] GLAXO GRP RES LTD, DEPT VIROL, GREENFORD UB6 0HE, MIDDX, ENGLAND

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1991年 / 10卷 / 1-3期

关键词：

D O I：

10.1080/07328319108046503

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of racemic carbocyclic analogues of Ribavirin have been prepared. Their degree of phosphorylation by adenosine kinase and the inhibition of IMPDH and RNA polymerase by their mono and triphosphates respectively is compared with Ribavirin and discussed in the context of anti-influenza activity.

引用

页码：487 / 490

页数：4

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