ENHANCEMENT OF LYMPHATIC TRANSPORT OF 1-(2-TETRAHYDROFURYL)-5-FLUOROURACIL BY WATER-IN-OIL EMULSION

被引：12

作者：

NAKAMOTO, Y ^{[1
]}

TAKEEDA, T ^{[1
]}

SAKIKAWA, F ^{[1
]}

MORIMOTO, K ^{[1
]}

MORISAKA, K ^{[1
]}

MURANISHI, S ^{[1
]}

SEZAKI, H ^{[1
]}

机构：

[1] KYOTO UNIV,FAC PHARMACEUT SCI,SAKYO KU,KYOTO 606,JAPAN

来源：

JOURNAL OF PHARMACOBIO-DYNAMICS | 1979年 / 2卷 / 01期

关键词：

anticancer agent; bile duct ligation; drug delivery system; electron micrograph; insitu loop absorption; oil droplet; water in oil emulsion;

D O I：

10.1248/bpb1978.2.45

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Enhancement of the lymphatic transport of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207), an orally active anticancer agent, was demonstrated by the administration of W/O emulsion into the loop of rat small intestine. The lymphatic transport of FT-207 was inhibited by the presence of bile. Absorption of oil in the absence of bile was confirmed by light microscopy. Electron micrograph revealed that oil droplets are mainly transported via the lymphatic system. © 1979, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：45 / 51

页数：7