REGULATION OF THE NATURAL-KILLER-CELL RESPONSE TO INTERFERON-ALPHA BY BIOGENIC-AMINES

被引：26

作者：

HELLSTRAND, K

KYLEFJORD, H

ASEA, A

HERMODSSON, S

机构：

[1] Department of Clinical Virology, University of Göteborg

来源：

JOURNAL OF INTERFERON RESEARCH | 1992年 / 12卷 / 03期

关键词：

D O I：

10.1089/jir.1992.12.199

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Monocytes, recovered from human peripheral blood by counter-current centrifugal elutriation (CCE), suppressed baseline natural killer (NK) cell cytotoxicity (NKCC) and rendered NK cells resistant to activation of cyotoxicity by human recombinant interferon-alpha (IFN-alpha) by a cell contact-dependent mechanism. Monocyte-induced suppression of resting and IFN-activated NK cells was abrogated by the biogenic amines histamine [via H-2-type receptors (H2R)] and serotonin [via 5-HT-1A-type receptors (5-HT(1A)R)]. Our data are suggestive of a monocyte/NK cell interaction that is subject to regulation by biogenic amines.

引用

页码：199 / 206

页数：8

共 34 条

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