HYALURONAN AND CELL LOCOMOTION

被引：182

作者：

TURLEY, EA ^{[1
]}

机构：

[1] UNIV MANITOBA, DEPT PEDIAT, WINNIPEG R3E 0V9, MANITOBA, CANADA

来源：

CANCER AND METASTASIS REVIEWS | 1992年 / 11卷 / 01期

关键词：

HYALURONAN; RHAMM; DIRECTED CELL LOCOMOTION; PROTEIN TYROSINE PHOSPHORYLATION;

D O I：

10.1007/BF00047600

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hyaluronan (HA), a glycosaminoglycan, has long been implicated in cell locomotion. We have shown that HA production regulates the locomotion of H-ras-transformed cells. This autocrine motility mechanism is mediated by a novel HA receptor termed RHAMM, an acronym for Receptor for HA Mediated Motility. HA: RHAMM interactions regulate directional locomotion of tumor cells and result in enhanced protein tyrosine phosphorylation that may be a critical messenger mechanism for initiation of locomotion.

引用

页码：21 / 30

页数：10

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