IMPORTANCE OF THE MOUSE-LIVER TUMOR IN CARCINOGENESIS BIOASSAY STUDIES USING BENZIDINE DIHYDROCHLORIDE AS A MODEL

被引：9

作者：

FRITH, CH ^{[1
]}

BAETCKE, KP ^{[1
]}

NELSON, CJ ^{[1
]}

SCHIEFERSTEIN, G ^{[1
]}

机构：

[1] NATL CTR TOXICOL RES,PATHOL SERV PROJ,JEFFERSON,AR 72079

来源：

TOXICOLOGY LETTERS | 1979年 / 4卷 / 06期

关键词：

D O I：

10.1016/0378-4274(79)90119-X

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Benzidine dihydrochloride induced hepatocellular adenomas in male and female mice which appeared to progress to hepatocellular carcinomas as either the length of administration and/or the dose level of benzidine increased. The differentiation of hepatocellular carcinomas also correlated inversely with dose, and poorly differentiated hepatocellular carcinomas metastasized more frequently. These findings support the view that the mouse liver tumor is predictive of carcinogenicity in bioassay studies. © 1979.

引用

页码：507 / 518

页数：12

共 13 条

[1] THE INDUCTION OF TUMOURS OF THE SUBCUTANEOUS TISSUES, LIVER AND INTESTINE IN THE MOUSE BY CERTAIN DYE-STUFFS AND THEIR INTERMEDIATES [J].

BONSER, GM ;

CLAYSON, DB ;

JULL, JW .

BRITISH JOURNAL OF CANCER, 1956, 10 (04) :653-&

[2]

FRITH CH, 1976, LAB ANIM SCI, V26, P171

[3] HEPATIC CYTOLOGIC AND NEOPLASTIC CHANGES IN MICE GIVEN BENZIDINE DIHYDROCHLORIDE [J].

FRITH, CH ;

DOOLEY, K .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1976, 56 (03) :679-682

[4]

FRITH CH, J ENV TOX PATHOL

[5]

INNES JRM, 1969, JNCI-J NATL CANCER I, V42, P1101

[6]

KYRIAZIS AP, 1974, CANCER RES, V34, P2881

[7]

Prokof'eva O G, 1971, Vopr Onkol, V17, P61

[8] PREDICTIVE VALUE OF MOUSE LIVER TUMOR INDUCTION IN CARCINOGENICITY TESTING - LITERATURE SURVEY [J].

TOMATIS, L ;

PARTENSKY, C ;

MONTESANO, R .

INTERNATIONAL JOURNAL OF CANCER, 1973, 12 (01) :1-20

[9]

TOMATIS L, 1972, Z KREBSFORSCH, V82, P25

[10]

VESSELINOVITCH SD, 1975, CANCER RES, V35, P2814

← 1 2 →