THE STRUCTURE AND PARTIAL SYNTHESIS OF IMBRICATINE, A BENZYLTETRAHYDROISOQUINOLINE ALKALOID FROM THE STARFISH DERMASTERIAS-IMBRICATA

被引：21

作者：

BURGOYNE, DL

MIAO, S

PATHIRANA, C

ANDERSEN, RJ

AYER, WA

SINGER, PP

KOKKE, WCMC

ROSS, DM

机构：

[1] UNIV BRITISH COLUMBIA,DEPT CHEM,VANCOUVER V6T 1W5,BC,CANADA

[2] UNIV BRITISH COLUMBIA,DEPT OCEANOG,VANCOUVER V6T 1W5,BC,CANADA

[3] UNIV ALBERTA,DEPT CHEM,EDMONTON T6G 2E9,ALBERTA,CANADA

[4] UNIV ALBERTA,CTR BIOL SCI,DEPT ZOOL,EDMONTON T6G 2E9,ALBERTA,CANADA

来源：

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE | 1991年 / 69卷 / 01期

关键词：

IMBRICATINE; ASTEROID; ALKALOID;

D O I：

10.1139/v91-004

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The structure of imbricatine (1), a cytotoxic metabolite of the starfish Dermasterias imbricata, has been determined by spectroscopic analysis and chemical degradation. Synthesis of model compounds 7 and 18 provided evidence for the absolute configuration and constitution of the benzyltetrahydroisoquinoline substructure of imbricatine.

引用

页码：20 / 27

页数：8

共 20 条

[1]

AYER WA, 1973, AM ZOOL, V13

[2]

BAN Y, 1958, CHEM PHARM BULL, V6, P574

[3]

Burnell D. J., 1983, MARINE NATURAL PRODU, P287

[4]

DYKE SF, 1981, HETEROCYCLIC COMPO 1, V38, P25